ATHENAHEALTH, INC. COMPLETES PURCHASE OF MAINE OPERATIONS CENTER

BELFAST, Maine (February 22, 2008) – athenahealth, Inc. (Nasdaq:ATHN), a leading provider of internet-based business services for physician practices, today announced that it has completed the purchase of its Maine Operations Center for $6.1 million. The facility, located in Belfast, Maine, includes more than 189,000 square feet of office space on a 53 acre campus.

“We are very excited about athenahealth’s expansion to Maine, and we look forward to commencing operations this spring,” said David Tassoni, Managing Director for athenahealth Maine. “We have received a wonderful reception from the people of the greater Belfast region during the past few months at our various recruiting events.”

The athenahealth Maine Operations Center is designed to be athenahealth’s second operational service location in the United Sates and to provide additional business capacity as the Company seeks to expand its service offerings and its network of physician clients.

About athenahealth

athenahealth is a leading provider of internet-based business services for physician practices. The Company’s service offerings are based on proprietary internet-based practice management and electronic medical record (EMR) software, a continuously updated payer knowledge-base and integrated back-office service operations. For more information visit www.athenahealth.com or call (888) 652-8200 .

This press release contains forward-looking statements which are made pursuant to the safe harbor provisions of Private Securities Litigation Reform Act of 1995, including statements regarding the benefits of the athenahealth’s service offerings. These statements are neither promises nor guarantees, and are subject to a variety of risks and uncertainties, many of which are beyond our control, which could cause actual results to differ materially from those contemplated in these forward-looking statements. In particular, the risks and uncertainties include, among other things: the risk that our services, facilities and systems will not operate in the manner that we expect or may not be available at the times that we expect, due to design flaws, security breaches or otherwise; potential interruptions or delays in our internet-based service offerings; our reliance upon third parties, such as builders and suppliers of computer hardware, software, data-hosting and internet infrastructure, which reliance may result in failures, disruptions or delay in our operations or facilities; and the evolving and complex government regulatory compliance environment in which we and our clients operate. Existing and prospective investors are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date hereof. athenahealth, Inc. undertakes no obligation to update or revise the information contained in this press release, whether as a result of new information, future events or circumstances or otherwise. For additional disclosure regarding these and other risks faced by athenahealth, Inc., see the disclosure contained in our public filings with the Securities and Exchange Commission and available on its investor relations website at http://www.athenahealth.com and on the SEC’s website at http://www.sec.gov, including athenahealth’s most recent Quarterly Report on Form 10-Q for the quarter ended September 30, 2007.

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Source: ATHENAHEALTH